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Previous episode How much weight do people lose on Ozempic? What the big trials found

How Ozempic works: why a diabetes shot makes people stop feeling hungry

Mounjaro and Zepbound: why tirzepatide works on two gut hormones

Tirzepatide, sold as Mounjaro and Zepbound, copies not one gut hormone but two. When it was tested against semaglutide, people lost more weight on it. Why would a second message help, when scientists cannot even agree on what that message does?

  1. 1 At the pharmacy, Miva now keeps a second kind of weekly pen. Its drug is tirzepatide. It is sold as Mounjaro for diabetes and as Zepbound for weight.semaglutidetirzepatideMiva

    At the pharmacy, Miva now keeps a second kind of weekly pen. Its drug is tirzepatide. It is sold as Mounjaro for diabetes and as Zepbound for weight.

  2. 2 After a meal, your gut sends more than one message. Next to GLP-1, other cells, higher up in the small intestine, send GIP. It is another hormone that helps the pancreas release insulin when sugar is high.higher upfurther downGIPGLP-1

    After a meal, your gut sends more than one message. Next to GLP-1, other cells, higher up in the small intestine, send GIP. It is another hormone that helps the pancreas release insulin when sugar is high.

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